电子邮件:christian.grinan@ub.edu
主要研究方向:衰老，阿尔茨海默病，神经炎症，神经保护，神经退行性变的表观遗传控制。
传记:ChristianGriñán-Ferré博士是巴塞罗那大学药房和食品科学教学助理。He received his Ph.D in the epigenetic modulation of Alzheimer’s Disease (AD) (Biomedical Biotechnology) at the University of Barcelona and Master degree in Anti-infective Therapy at Omnia Molecular S.A. He has participated in 9 competitive research projects in neuropharmacology of aging and collaborate with Oryzon Genomics SA. Scientific outcome: 18 original papers in indexed journals (all in the Q1) with a number of citations 150 and 3 patent applications. H-index: 8. Expert in behavioral studies, cell biology, biochemistry, molecular techniques, biotechnology, and bioinformatics analysis. During his research, He focused his knowledge in the epigenetic modulation of neurodegeneration and AD. Furthermore, the study of non-pharmacological interventions such as Environmental Enrichment (EE) paradigms to find new targets to prevent or cure the neurodegeneration. Currently, He is working as a post-doctoral researcher at Neuropharmacology in aging and neurodegeneration (Neuroscience Institute, UB). He is in a multidisciplinary group interested in the identification of new targets to achieve preventive or curative strategies by reducing inflammation, mitochondrial dysfunction, endoplasmic reticulum (ER) stress and oxidative stress (OS) in pathological senescence and the crossroad with epigenetics. Using his background knowledge in order to organise pharmacological (melatonin, resveratrol and new chemical entities) and non-pharmacological (environmental enrichment paradigms, exercise, caloric restriction) strategies to ameliorate and prevent them with several mice models of neurodegeneration and AD such as SAMP8 and 5xFAD. Recently, He has initiated studies with new compounds acting in putative new targets implicated in neuroinflammation and oxidative stress. In parallel, He performs epigenetic studies with these mice and with a new murine model of Niemann-Pick Type C (NPC) in order to characterise epigenetic changes for this rare disease that might underlie cognitive impairment and neurodegeneration.
技术/方法:
- 分子生物学标准方法:蛋白质水平测定，基因转录定量，免疫组织化学方法，共聚焦显微镜。
- 认知测试:学习、记忆和BSPD。
