Background : Laryngo-pharyngeal reflux disease and laryngo-pharyngeal symptoms and signs are common and increasing disorder mainly in pediatric patients . Frequency of LPR with laryngeal-pharyngeal issues and its response to combination or multiple medical treatment need to be clarified. Objective : To determine the singes and symptoms  LPR in Pediatric patients and to assess its response to combination of medical treatment with anti- acid (H2RA/PPI ) and leukotriene receptor antagonist like (Singular ; montelukast). Method : 650 patients were diagnosed as having LPR and medical therapy was given for most of them .then the effect of 1 month of combination treatment of anti-acid and leukotriene receptor antagonist was assessed. Results : male patients formed 65% of all patients, most of patients  have nasal obstruction with snoring and nocturnal cough and vomiting with throat discomfort and above  90% of them improved almost completely and significantly (p> 0.001) on this treatment especially snoring, nocturnal cough, vomiting  and voice quality issues after combination treatment for 1 month. Conclusion : LPR is an increasing disease in pediatric patients may be due newly changing of life style, bad feeding habits in Arab Gulf Ares ,allergy to food, and there was positive impact that combination medical treatment reduce the need for further prolonged treatment and more investigations.

背景：喉咽反流病和喉咽症状和体征是常见的和日益增加的疾病，主要发生在儿童患者中。有喉咽问题的LPR发生率及其对联合或多种药物治疗的反应有待澄清。前言：目的：明确临床症状和体征儿童LPR及其对抗酸（H2RA/PPI）和白三烯受体拮抗剂样药物联合治疗的反应；孟鲁司特）。方法：对650例确诊为LPR的患者进行药物治疗，观察抗酸及白三烯受体拮抗剂联合治疗1个月的疗效。结果：男性患者占65%，以男性患者居多鼻塞伴打鼾，夜间咳嗽、呕吐伴咽喉不适及以上治疗后90%的患者几乎完全好转（p>0.001），尤其是打鼾、夜间咳嗽、呕吐联合治疗1个月后语音质量问题。结论：LPR在儿童中呈上升趋势，可能与生活方式的新变化、阿拉伯海湾地区不良的饮食习惯、食物过敏有关，联合用药减少了进一步延长治疗时间和进一步调查的必要性。