we conducted a prospective randomized trial including patients with physical status ASA I or II and proposed for laparoscopic cholecystectomy.
Thirty not premeditated patients aged more than 18 years, were randomized to be allocated to:
· Group VC: classic ventilation 8cc/Kg of ideal body weight (IBW), PEP=5, I/E=1/2
· Group VP: protective ventilation 6cc/Kg of IBW, PEP=8, I/E=1/2, and hyperventilation at closure time.
Anesthesiologists in charged with post-operative evaluation are blinded to the patient’s allocation.
The primary outcome was the quality of postoperative analgesia. VAS was measured at H0, H2, H6, H12 and H24. The secondary outcome was enhanced post-operative recovery.
Results: We found that protective ventilation associated with hyperventilation at the end of laparoscopic surgery can significantly reduce postoperative pain, and morphine consumption leading to an enhanced post-operative recovery.
Conclusion: Protective ventilation associated with end surgery hyperventilation may reduce post-operative pain and allow an enhanced recovery. However, a larger sample size is needed to have more representative results. Dosage of inflammation’s mediators should be considered
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·
VC组:经典通气8cc/Kg理想体重(IBW)， PEP=5, I/E=1/2
·
VP组:保护性通气6cc/Kg IBW, PEP=8, I/E=1/2，闭合时过度通气。
负责术后评估的麻醉师对病人的分配是不知情的。
主要结果是术后镇痛的质量。在H0、H2、H6、H12、H24时测量VAS。次要结果是术后恢复增强。
结果:我们发现，在腹腔镜手术结束时与过度通气相关的保护性通气可显著减少术后疼痛，吗啡的消耗可促进术后恢复。
结论:与术后过度通气相关的保护性通气可减少术后疼痛并促进恢复。然而，需要更大的样本量才能得到更有代表性的结果。应考虑炎症介质的剂量
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