摘要：

背景:贫血是慢性肾衰竭患者血液透析治疗的主要健康问题，而促红细胞生成素是治疗的首选药物，有些患者的治疗效果不如预期。多种研究表明，锌可能在红细胞生成素抗性贫血的病因学中发挥作用。目的:探讨苏丹红细胞生成素抵抗血液透析患者血清锌水平及其与血红蛋白的关系，并与明显非红细胞生成素抵抗血液透析患者进行比较。材料和方法:病例对照研究于2018年2月至10月期间在喀土穆州的肾病诊所进行。取促红细胞生成素耐药血液病患者50例。另外50例为非抗红细胞生成素血症患者，性别和年龄相匹配的对照组。用原子吸收光谱法测定各组血清锌元素水平，用比色法测定血红蛋白水平。结果:红细胞生成素抵抗性血液透析患者的血清锌水平显著低于非红细胞生成素抵抗性血液透析患者对照组(0.26±0.08 mg/L vs 0.67±0.09 mg/)。Hb显著降低(8.56±0.56 gm/L vs 11.34±0.59 gm/dl)。p = 0.000)。此外，研究还发现试验组的锌水平和血红蛋白在性别上没有显著差异(P > 0,05)。 Also the study recorded serum zinc level is significantly correlated with Hb(R=0.58,P = 0.00), and inversely correlated with age(R= - 43.P=0.01). whereas Hb level is insiginificantly correlated with patients age in the study group ( R =0.24 . p = 0.16). Conclusion: erythropiotin resistant anemia in haemodialysis patients is associated with reduced serum zinc level. Which provide evidence that serum zinc levels should be measure especially in haemodylasis patients resistant to erythropiotin therapy.